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Not just its sum but will also the functional Attributes of Hb have an effect on functionality. This is illustrated from the observation that an increased Hb-O2 affinity favors O2 loading in the lung and survival in an hypoxic atmosphere (Eaton et al., 1974; Hebbel et al., 1978), Whilst a lowered Hb-O2 affinity favors the discharge of O2 in the Hb